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Sarcopenia指随着年龄的增加,机体骨骼肌质量、力量及功能逐渐下降的现象,它的发生增加了老年人的健康维护成本,给家庭及社会带来沉重经济负担。Sarcopenia的病理生理过程非常复杂,涉及细胞凋亡、氧化应激、蛋白质合成减少、骨骼肌废用、炎症反应、线粒体功能障碍等,并与骨骼肌质量控制(蛋白质质量控制和肌纤维数目控制)失衡密切相关。AMPK(AMP-activated protein kinase)、Sirt1(silencing information reg-ulator1)是机体内重要的能量代谢感受器,可感知体内的能量代谢状态,通过改变下游分子的基因表达或活性调节机体能量代谢过程。AMPK/Sirt1信号通路通过对细胞自噬、细胞凋亡、细胞增殖与分化、骨骼肌蛋白合成与降解、炎症反应等过程对的调控影响骨骼肌质量与功能,这可能与机体衰老过程中Sarcopenia的发生、发展及转归密切相关。研究表明,运动可促进骨骼肌蛋白质合成、增加机体的瘦体重,达到预防和治疗Sarcopenia的目的,但运动所引起的AMPK/Sirt1信号通路及其调控下游细胞事件的适应性改变与Sarcopenia的内在联系尚不明确。本文通过对AMPK/Sirt1信号通路与骨骼肌蛋白合成、降解和细胞凋亡等信号通路的关系及其运动调控进行综述,以期深入了解运动、AMPK/Sirt1信号通路与Sarcopenia的内在关系,旨为Sarcopenia的运动防治提供新思路。
Abstract：arcopenia refers to the age-associated loss of skeletal muscle mass and function,which contributes to the disturbance of muscle mass control. The prevalence of sarcopenia leads to an increase in healthcare expenditures and imposes a significant economic burden on home-based and government-reimbursed healthcare services. The pathogenesis of sarcopenia is complex and multiple cellular events including apoptosis,oxidative stress,disuse,inflammation,mitochondrial dysfunction and the decreased synthesis of muscle protein. AMPK/Sirt1 pathway,as primary sensors of energy status,plays an important role in the skeletal muscle mass control and energy metabolism,in which not only protein turnover containing protein synthesis and degradation but also cell survival progresses containing autophagy,inflammation and apoptosis are involved. Previous studies suggested that regular exercise can promote the synthesis of protein in skeletal muscle to ameliorate the symptom of sarcopenia,however the molecular mechanism has not been uncovered. The crosstalk between AMPK/Sirt1 signaling pathway and its downstream cellular events adaptation induced by exercise may play an important role in the prevention of sarcopenia.In this paper,we reviewed on the AMPK/Sirt1 pathway and its molecular mechanism on the muscle mass control to reveal the pathological and physiological mechanism of the sarcopenia and provide a novel avenue on its prevention and therapy induced by exercise.
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基本信息:
DOI：10.13297/j.cnki.issn1005-0000.2014.03.002
中图分类号:G804.2
引用信息:
[1]邱守涛,崔迪,卢健,等.AMPK/Sirt1信号通路在运动调控骨骼肌质量中的作用[J].天津体育学院学报,2014,29(03):255-258+271.DOI:10.13297/j.cnki.issn1005-0000.2014.03.002.
基金信息:
青少年健康评价与运动干预教育部重点实验室建设项目(项目编号:40500-541235-14203/004);; 上海市浦江人才计划(项目编号:10PJC029)